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Anti-Smac/Diablo Antibody

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ABclonal
A0853
Overview
Name: Anti-Smac/Diablo Antibody
Description: Rabbit polyclonal antibody to Smac/Diablo.
Applications: WB, IHC, FC
Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:100, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human DIABLO
Protein Length: 239
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Tissue Specificity: Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.
Involvement in Disease: Deafness, autosomal dominant, 64: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Post-Translational Modification: Ubiquitinated by BIRC7/livin.
Cellular Location: Mitochondrion.

Released into the cytosol when cells undergo apoptosis.
UniProt: Q9NR28
Gene ID: 56616

Images
Western Blot - Anti-Smac/Diablo Antibody from ABclonal (A0853) - Antibody Supply Service
Western blot analysis of extracts of HepG2 cells lines, using DIABLO antibody.

Product Code - A0853
Size Price Quantity
100µl £243
200µl £372

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