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Anti-Integrin α5 Antibody

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Name: Anti-Integrin α5 Antibody
Description: Rabbit polyclonal antibody to Integrin α5.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:100
Reactivity: Human
Immunogen: A synthetic peptide of human ITGA5
Protein Length: 1049
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
Sequence Similarities: Belongs to the integrin alpha chain family.
Post-Translational Modification: Proteolytic cleavage by PCSK5 mediates activation of the precursor.
Cellular Location: Membrane. Cell junction > Focal adhesion. Cell surface.
UniProt: P08648
Gene ID: 3678

Western Blot - Anti-Integrin α5 Antibody from ABclonal (A0832) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using ITGA5 antibody.

Product Code - A0832
Size Price Quantity
100µl £243
200µl £372

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