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Anti-SUMO1 Antibody

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Name: Anti-SUMO1 Antibody
Description: Rabbit polyclonal antibody to SUMO1.
Applications: WB, IHC, IF, FC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:20 - 1:50, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human SUMO1
Protein Length: 101
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).
Involvement in Disease: Non-syndromic orofacial cleft 10: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
Sequence Similarities: Belongs to the ubiquitin family. SUMO subfamily.
Post-Translational Modification: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
Cellular Location: Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus > PML body. Cell membrane. Nucleus.

Recruited by BCL11A into the nuclear body. In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body.
UniProt: P63165
Gene ID: 7341
Synonyms: DAP1 Antibody
GAP modifying protein 1 Antibody
GAP-modifying protein 1 Antibody
GMP 1 Antibody
GMP1 Antibody
OFC10 Antibody
PIC 1 Antibody
PIC1 Antibody
SENP2 Antibody
Sentrin Antibody
Sentrin 1 Antibody
Small ubiquitin related modifier 1 Antibody
Small ubiquitin-like modifier 1 Antibody
Small ubiquitin-related modifier 1 Antibody
SMT3 Antibody
SMT3 homolog 3 Antibody
SMT3 suppressor of mif two 3 homolog 1 Antibody
SMT3, yeast, homolog 3 Antibody
Smt3C Antibody
SMT3H3 Antibody
Sumo 1 Antibody
SUMO-1 Antibody
SUMO1_HUMAN Antibody
Ubiquitin homology domain protein PIC1 Antibody
Ubiquitin Like 1 Antibody
Ubiquitin like protein SMT3C Antibody
Ubiquitin like protein UBL1 Antibody
Ubiquitin-homology domain protein PIC1 Antibody
Ubiquitin-like protein SMT3C Antibody
Ubiquitin-like protein UBL1 Antibody
UBL 1 Antibody
UBL1 Antibody

Western Blot - Anti-SUMO1 Antibody from ABclonal (A0825) - Antibody Supply Service
Western blot analysis of NIH3T3 cell lysate using SUMO1 antibody.

Product Code - A0825
Size Price Quantity
100µl £243
200µl £372

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