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Anti-SNAP25 Antibody

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ABclonal
A0795
Overview
Name: Anti-SNAP25 Antibody
Description: Rabbit polyclonal antibody to SNAP25.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: A synthetic peptide of human SNAP25
Protein Length: 206
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.
Tissue Specificity: Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.
Involvement in Disease: Myasthenic syndrome, congenital, 18: A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS18 is an autosomal dominant presynaptic disorder clinically characterized by early-onset muscle weakness and easy fatigability associated with delayed psychomotor development and ataxia.
Sequence Similarities: Belongs to the SNAP-25 family.
Post-Translational Modification: Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association (By similarity).
Cellular Location: Cytoplasm > Perinuclear region. Cell membrane. Cell junction > Synapse > Synaptosome.

Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region. Colocalizes with KCNB1 at the cell membrane (By similarity).
UniProt: P60880
Gene ID: 6616
Synonyms: bA416N4.2 Antibody
Bdr Antibody
CMS18 Antibody
dJ1068F16.2 Antibody
FLJ23079 Antibody
HGNC:11132 Antibody
MGC105414 Antibody
MGC139754 Antibody
Resistance to inhibitors of cholinesterase 4 homolog Antibody
RIC 4 Antibody
RIC4 Antibody
SEC 9 Antibody
SEC9 Antibody
SNAP Antibody
SNAP 25 Antibody
SNAP-25 Antibody
SNAP-25B Antibody
SNAP25 (phospho S187) Antibody
SNP 25 Antibody
SNP25 Antibody
SNP25_HUMAN Antibody
sp Antibody
SUP Antibody
Super protein Antibody
Synaptosomal associated 25 kDa protein Antibody
Synaptosomal associated protein Antibody
Synaptosomal associated protein 25 Antibody
Synaptosomal associated protein 25kDa Antibody
Synaptosomal-associated 25 kDa protein Antibody
Synaptosomal-associated protein 25 Antibody
Synaptosomal-associated protein, 25-KD Antibody

Images
Western Blot - Anti-SNAP25 Antibody from ABclonal (A0795) - Antibody Supply Service
Western blot analysis of extracts of SH-SY5Y cells, using SNAP25 antibody.

Product Code - A0795
Size Price Quantity
100µl £243
200µl £372

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