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Anti-Vav1 Antibody

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Description: Mouse monoclonal antibody to Vav1.
Category: Primary Antibodies
Applications: WB
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Reactivity: Human
UniProt: P15498
Gene ID: 7409
Immunogen: Recombinant protein of human VAV1
Protein Length: 845
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: VAV
Purification: Affinity purification
Background: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000

Target (Information from UniProt)
Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Tissue Specificity: Widely expressed in hematopoietic cells but not in other cell types.
Post-Translational Modification: Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity). Phosphorylated by FYN.

Western Blot - Anti-Vav1 Antibody from ABclonal (A0770) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using VAV1 antibody.

Product Code - A0770
Size Price Quantity
100µl £243
200µl £372

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