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Anti-Annexin A1 Antibody

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ABclonal
A0767
Overview
Name: Anti-Annexin A1 Antibody
Description: Rabbit polyclonal antibody to Annexin A1.
Applications: WB, IHC, FC
Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:100, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human ANXA1
Protein Length: 346
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
Tissue Specificity: Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.
Sequence Similarities: Belongs to the annexin family.
Post-Translational Modification: Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879). Phosphorylated in response to EGF treatment (PubMed:2532504).
Cellular Location: Nucleus. Cytoplasm. Cell projection > Cilium. Cell membrane. Membrane. Endosome membrane. Basolateral cell membrane. Apical cell membrane. Lateral cell membrane. Secreted. Secreted > Extracellular space. Cell membrane. Secreted > Exosome. Cytoplasmic vesicle > Secretory vesicle lumen. Cell projection > Phagocytic cup. Early endosome. Cytoplasmic vesicle membrane.

Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678).
UniProt: P04083
Gene ID: 301
Synonyms: Annexin 1 Antibody
Annexin I Antibody
Annexin I (lipocortin I) Antibody
Annexin-1 Antibody
AnnexinA1 Antibody
AnnexinI Antibody
ANX 1 Antibody
ANX A1 Antibody
ANX1 Antibody
ANXA 1 Antibody
ANXA1 Antibody
ANXA1 protein Antibody
ANXA1_HUMAN Antibody
Calpactin 2 Antibody
Calpactin II Antibody
Calpactin-2 Antibody
CalpactinII Antibody
Chromobindin 9 Antibody
Chromobindin-9 Antibody
Chromobindin9 Antibody
HGNC:533 Antibody
Lipocortin 1 Antibody
Lipocortin I Antibody
Lipocortin1 Antibody
LipocortinI Antibody
LPC 1 Antibody
LPC1 Antibody
p35 Antibody
Phospholipase A2 inhibitory protein Antibody

Images
Western Blot - Anti-Annexin A1 Antibody from ABclonal (A0767) - Antibody Supply Service
Western blot analysis of extracts of A2058 cells, using ANXA1 antibody.

Product Code - A0767
Size Price Quantity
100µl £243
200µl £372

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