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Anti-NCOA1 Antibody

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ABclonal
A0765
Overview
Name: Anti-NCOA1 Antibody
Description: Rabbit polyclonal antibody to NCOA1.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: A synthetic peptide of human NCOA1
Protein Length: 1441
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
Tissue Specificity: Widely expressed.
Sequence Similarities: Belongs to the SRC/p160 nuclear receptor coactivator family.
Post-Translational Modification: Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.
Cellular Location: Nucleus.
UniProt: Q15788
Gene ID: 8648
Synonyms: bHLHe74 Antibody
Class E basic helix-loop-helix protein 74 Antibody
F SRC 1 Antibody
Hin 2 protein Antibody
Hin2 protein Antibody
KAT13A / SRC1 Antibody
MGC129719 Antibody
MGC129720 Antibody
mNRC 1 Antibody
NCoA 1 Antibody
NCoA-1 Antibody
NCOA1_HUMAN Antibody
Nuclear receptor coactivator 1 Antibody
Nuclear receptor coactivator protein 1 Antibody
NY REN 52 antigen Antibody
Protein Hin 2 Antibody
Protein Hin-2 Antibody
Protein Hin2 Antibody
Renal carcinoma antigen NY REN 52 Antibody
Renal carcinoma antigen NY-REN-52 Antibody
RIP 160 Antibody
RIP160 Antibody
SRC 1 Antibody
SRC-1 Antibody
Steroid receptor coactivator 1 Antibody

Images
Western Blot - Anti-NCOA1 Antibody from ABclonal (A0765) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using NCOA1 antibody.

Product Code - A0765
Size Price Quantity
100µl £243
200µl £372

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