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Anti-FADD Antibody

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Name: Anti-FADD Antibody
Description: Rabbit polyclonal antibody to FADD.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: A synthetic peptide of human FADD
Protein Length: 208
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Tissue Specificity: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Involvement in Disease: Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations: A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV).
UniProt: Q13158
Gene ID: 8772
Synonyms: FADD (phospho S191) Antibody
FADD (phospho S194) Antibody
FADD protein Antibody
Fas (TNFRSF6) associated via death domain Antibody
Fas associated via death domain Antibody
Fas associating death domain containing protein Antibody
Fas associating protein Antibody
Fas associating protein with death domain Antibody
Fas TNFRSF6 associated via death domain Antibody
FAS-associated death domain protein Antibody
FAS-associating death domain-containing protein Antibody
GIG 3 Antibody
GIG3 Antibody
Growth inhibiting gene 3 protein Antibody
Growth-inhibiting gene 3 protein Antibody
H sapiens mRNA for mediator of receptor induced toxicity Antibody
Mediator of receptor induced toxicity Antibody
MGC8528 Antibody
MORT 1 Antibody
MORT1 Antibody
Protein FADD Antibody

Western Blot - Anti-FADD Antibody from ABclonal (A0759) - Antibody Supply Service
Western blot analysis of extracts of HT1080 cell line, using FADD antibody.

Product Code - A0759
Size Price Quantity
100µl £243
200µl £372

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