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Anti-JAK3 Antibody

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ABclonal
A0748
Overview
Name: Anti-JAK3 Antibody
Description: Rabbit polyclonal antibody to JAK3.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: A synthetic peptide of human JAK3
Protein Length: 1124
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
Tissue Specificity: In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins.
Involvement in Disease: Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Post-Translational Modification: Tyrosine phosphorylated in response to IL-2 and IL-4. Dephosphorylation of Tyr-980 and Tyr-981 by PTPN2 negatively regulates cytokine-mediated signaling (Probable).
Cellular Location: Endomembrane system. Cytoplasm.
UniProt: P52333
Gene ID: 3718
Synonyms: EC 2.7.10.2 Antibody
JAK 3 Antibody
JAK L Antibody
JAK-3 Antibody
JAK3 (phospho Y785) Antibody
JAK3 HUMAN Antibody
JAK3_HUMAN Antibody
JAKL Antibody
Janus kinase 3 Antibody
Janus kinase 3 (a protein tyrosine kinase, leukocyte) Antibody
Janus Kinase3 Antibody
L JAK Antibody
L-JAK Antibody
Leukocyte janus kinase Antibody
LJAK Antibody
Protein tyrosine kinase leukocyte Antibody
Tyrosine protein kinase JAK3 Antibody
Tyrosine-protein kinase JAK3 Antibody

Images
Western Blot - Anti-JAK3 Antibody from ABclonal (A0748) - Antibody Supply Service
Western blot analysis of extracts of TF-1 cell line, using JAK3 antibody.

Product Code - A0748
Size Price Quantity
50µl £148
100µl £243
200µl £372

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