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Anti-Topoisomerase IIα Antibody

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Name: Anti-Topoisomerase IIα Antibody
Description: Rabbit polyclonal antibody to Topoisomerase IIα.
Applications: WB, IHC, IF
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human TOP2A
Protein Length: 1531
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).
Sequence Similarities: Belongs to the type II topoisomerase family.
Post-Translational Modification: Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.
Cellular Location: Cytoplasm. Nucleus > Nucleoplasm.

Generally located in the nucleoplasm.
UniProt: P11388
Gene ID: 7153

Western Blot - Anti-Topoisomerase IIα Antibody from ABclonal (A0726) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using TOP2A antibody.

Product Code - A0726
Size Price Quantity
100µl £243
200µl £372

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