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Anti-PDIA1 Antibody

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Name: Anti-PDIA1 Antibody
Description: Rabbit polyclonal antibody to PDIA1.
Applications: WB, IHC, FC
Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:200, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human P4HB
Protein Length: 508
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).
Involvement in Disease: Cole-Carpenter syndrome 1: A form of Cole-Carpenter syndrome, a disorder characterized by features of osteogenesis imperfecta such as bone deformities and severe bone fragility with frequent fractures, in association with craniosynostosis, ocular proptosis, hydrocephalus, growth failure and distinctive facial features. Craniofacial findings include marked frontal bossing, midface hypoplasia, and micrognathia. Despite the craniosynostosis and hydrocephalus, intellectual development is normal. CLCRP1 inheritance is autosomal dominant.
Sequence Similarities: Belongs to the protein disulfide isomerase family.
Cellular Location: Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane.

Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces (PubMed:11181151). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:10636893). Colocalizes with MTTP in the endoplasmic reticulum (PubMed:23475612).
UniProt: P07237
Gene ID: 5034
Synonyms: Cellular thyroid hormone binding protein Antibody
Cellular thyroid hormone-binding protein Antibody
Collagen prolyl 4 hydroxylase beta Antibody
Disulphide Isomerase Antibody
DSI Antibody
EC Antibody
Endoplasmic reticulum resident protein 59 Antibody
ER protein 59 Antibody
ERBA2L Antibody
ERp59 Antibody
GIT Antibody
Gltathione insulin transhydrogenase Antibody
Glutathione insulin transhydrogenase Antibody
P4HB Antibody
P4Hbeta Antibody
p55 Antibody
PDI Antibody
PDIA1_HUMAN Antibody
PDIR Antibody
PHDB Antibody
PO4DB Antibody
PO4HB Antibody
Procollagen proline 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase) beta polypeptide (protein disulfide isomerase associated 1) Antibody
Procollagen proline 2 oxoglutarate 4 dioxygenase beta subunit Antibody
PROHB Antibody
Prolyl 4 hydroxylase beta polypeptide Antibody
Prolyl 4 hydroxylase beta subunit Antibody
Prolyl 4 hydroxylase subunit beta Antibody
Prolyl 4-hydroxylase subunit beta Antibody
Protein disulfide isomerase associated 1 Antibody
Protein disulfide isomerase, family A, member 1 Antibody
Protein disulfide isomerase/oxidoreductase Antibody
Protein disulfide-isomerase Antibody
Protocollagen hydroxylase Antibody
Thbp Antibody
Thyroid hormone binding protein p55 Antibody
Thyroid hormone binding protein p55 cellular Antibody
V erb a avian erythroblastic leukemia viral oncogene homolog 2 like Antibody

Western Blot - Anti-PDIA1  Antibody from ABclonal (A0709) - Antibody Supply Service
Western blot analysis of COLO320 cell lysate using P4HB antibody.

Product Code - A0709
Size Price Quantity
100µl £243
200µl £372

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