phone icon
+44 (0)1223 298875

Anti-MeCP2 Antibody

file icon Datasheet
ABclonal
A0706
Overview
Name: Anti-MeCP2 Antibody
Description: Rabbit polyclonal antibody to MeCP2.
Applications: WB, IHC, FC
Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:100, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human MECP2
Protein Length: 486
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Tissue Specificity: Present in all adult somatic tissues tested.
Involvement in Disease: Angelman syndrome: A neurodevelopmental disorder characterized by severe motor and intellectual retardation, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, open-mouthed expression revealing the tongue.

Mental retardation, X-linked, syndromic, 13: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXS13 patients manifest mental retardation associated with other variable features such as spasticity, episodes of manic depressive psychosis, increased tone and macroorchidism.

Rett syndrome: An X-linked dominant neurodevelopmental disorder, and one of the most common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age, then gradually lose speech and purposeful hand movements, and develop microcephaly, seizures, autism, ataxia, mental retardation and stereotypic hand movements. After initial regression, the condition stabilizes and patients usually survive into adulthood.

Autism, X-linked 3: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.

Encephalopathy, neonatal severe, due to MECP2 mutations: A neurodevelopmental disorder characterized by severe neonatal encephalopathy, developmental delay, mental retardation, microcephaly, seizures. Additional features include respiratory insufficiency and central hypoventilation, gastroesophageal reflux, axial hypotonia, hyperreflexia and dyskinetic movements.

Mental retardation, X-linked, syndromic, Lubs type: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSL patients manifest mental retardation associated with variable features. They include swallowing dysfunction and gastroesophageal reflux with secondary recurrent respiratory infections, hypotonia, mild myopathy and characteristic facies such as downslanting palpebral fissures, hypertelorism and a short nose with a low nasal bridge.
Post-Translational Modification: Phosphorylated on Ser-423 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation.
Cellular Location: Nucleus.

Colocalized with methyl-CpG in the genome.
UniProt: P51608
Gene ID: 4204
Synonyms: AUTSX 3 Antibody
AUTSX3 Antibody
DKFZp686A24160 Antibody
Mbd 5 Antibody
Mbd5 Antibody
MECP 2 Antibody
MeCP 2 protein Antibody
MeCP-2 protein Antibody
MECP2_HUMAN Antibody
Methyl CpG binding protein 2 Antibody
Methyl CpG binding protein 2 (Rett syndrome) Antibody
Methyl-CpG-binding protein 2 Antibody
MRX 16 Antibody
MRX 79 Antibody
MRX16 Antibody
MRX79 Antibody
MRXS 13 Antibody
MRXS13 Antibody
MRXSL Antibody
PPMX Antibody
RS Antibody
RTS Antibody
RTT Antibody
WBP 10 Antibody
WBP10 Antibody

Images
Western Blot - Anti-MeCP2 Antibody from ABclonal (A0706) - Antibody Supply Service
Western blot analysis of extracts of MDA-MB435 cell line, using MECP2 antibody.

Product Code - A0706
Size Price Quantity
100µl £243
200µl £372

or
Request a quotation
Contact us directly to order
  • call icon +44 (0)1223 298875
  • +44 (0)1223 281447
  • email icon orders@ab-y-ss.com
Product Quality
  • guarantee icon
  • We promise guaranteed product quality
  • and expert customer service.
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe