|Description:||Rabbit polyclonal antibody to TJP1.|
|Applications:||WB, IHC, IF, IP, FC|
|Dilutions:||WB 1:200 - 1:500, IHC 1:50 - 1:200, IF 1:50 - 1:200, IP 1:20 - 1:50, FC 1:20 - 1:50|
|Immunogen:||Recombinant Protein of human TJP1|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.|
|Tissue Specificity:||The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.|
|Sequence Similarities:||Belongs to the MAGUK family.|
|Post-Translational Modification:||Phosphorylated. Dephosphorylated by PTPRJ.|
|Cellular Location:||Cell membrane. Cell junction > Tight junction. Cell junction. Cell junction > Gap junction.
Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells.
|Synonyms:||Tight junction protein 1 Antibody
Tight junction protein ZO-1 Antibody
Tight junction protein ZO1 Antibody
ZO1 tight junction protein Antibody
Zona occludens 1 Antibody
Zona occludens 1 protein Antibody
Zona occludens protein 1 Antibody
Zonula occludens 1 protein Antibody
Zonula occludens protein 1 Antibody
Western blot analysis of extracts of various cell lines, using TJP1 antibody.