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Anti-ESR2 Antibody

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Name: Anti-ESR2 Antibody
Description: Rabbit polyclonal antibody to ESR2.
Applications: WB, FC
Dilutions: WB 1:500 - 1:1000, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human ESR2
Protein Length: 530(472)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Tissue Specificity: Isoform 1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform 2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform 4 is found in testis. Isoform 5 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform 6 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
Sequence Similarities: Belongs to the nuclear hormone receptor family. NR3 subfamily.
Post-Translational Modification: Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.
Cellular Location: Nucleus.
UniProt: Q92731
Gene ID: 2100
Synonyms: Atherosclerosis, susceptibility to, included Antibody
DKFZp686N23123 Antibody
ER Antibody
ER Alpha Antibody
ER Beta Antibody
ER-alpha Antibody
ER-beta Antibody
Era Antibody
ERalpha Antibody
Erb Antibody
Erb2 Antibody
ERbeta Antibody
ER[a] Antibody
ER[b] Antibody
ESR Antibody
ESR B Antibody
ESR BETA Antibody
ESR1 Antibody
ESR1_HUMAN Antibody
ESR2_HUMAN Antibody
ESRA Antibody
ESRB Antibody
Estr Antibody
Estra Antibody
Estradiol receptor Antibody
Estradiol Receptor alpha Antibody
Estradiol Receptor beta Antibody
ESTRB Antibody
estrogen nuclear receptor beta variant a Antibody
estrogen nuclear receptor beta variant b Antibody
Estrogen Receptor Antibody
Estrogen Receptor 1 Antibody
Estrogen receptor 1 (alpha) Antibody
Estrogen Receptor 2 Antibody
Estrogen receptor 2 (ER beta) Antibody
Estrogen receptor 2 ER beta Antibody
Estrogen receptor alpha Antibody
Estrogen Receptor beta Antibody
Estrogen Receptor beta (phospho S105) Antibody
Estrogen receptor beta 4 Antibody
Estrogen resistance, included Antibody
HDL cholesterol, augmented response of, to hormone replacement, included Antibody
Myocardial infarction, susceptibility to, included Antibody
NR3A1 Antibody
NR3A2 Antibody
Nuclear receptor subfamily 3 group A member 1 Antibody
Nuclear receptor subfamily 3 group A member 2 Antibody
OTTHUMP00000017718 Antibody
OTTHUMP00000017719 Antibody

Western Blot - Anti-ESR2 Antibody from ABclonal (A0658) - Antibody Supply Service
Western blot analysis of extracts of SH-SY5Y cells tissue, using ESR2 antibody.

Product Code - A0658
Size Price Quantity
100µl £243
200µl £372

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