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Anti-ESR2 Antibody

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ABclonal
A0658
Details
Description: Rabbit polyclonal antibody to ESR2.
Category: Primary Antibodies
Applications: WB, FC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q92731
Gene ID: 2100
Immunogen: A synthetic peptide of human ESR2
Protein Length: 530(472)
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2
Purification: Affinity purification
Background: Estrogen receptor-beta (ESR2) is a member of the superfamily of nuclear receptors, which can transduce extracellular signals into transcriptional responses. It binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:1000, FC 1:20 - 1:50

Target (Information from UniProt)
Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Tissue Specificity: Isoform 1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform 2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform 4 is found in testis. Isoform 5 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform 6 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
Sequence Similarities: Belongs to the nuclear hormone receptor family. NR3 subfamily.
Post-Translational Modification: Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.
Cellular Location: Nucleus.

Images
Western Blot - Anti-ESR2 Antibody from ABclonal (A0658) - Antibody Supply Service
Western blot analysis of extracts of SH-SY5Y cells tissue, using ESR2 antibody.

Product Code - A0658
Size Price Quantity
100µl £243
200µl £372

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