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Anti-Profilin-1 Antibody

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ABclonal
A0639
Overview
Name: Anti-Profilin-1 Antibody
Description: Rabbit polyclonal antibody to Profilin-1.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: A synthetic peptide of human PFN1
Protein Length: 140
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Tissue Specificity: Expressed in epididymis (at protein level).
Involvement in Disease: Amyotrophic lateral sclerosis 18: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Sequence Similarities: Belongs to the profilin family.
Post-Translational Modification: Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.
Cellular Location: Cytoplasm > Cytoskeleton.
UniProt: P07737
Gene ID: 5216
Synonyms: Actin binding protein Antibody
ALS18 Antibody
Epididymis tissue protein Li 184a Antibody
OTTHUMP00000125244 Antibody
Pfn Antibody
PFN 1 Antibody
PFN1 Antibody
PROF1_HUMAN Antibody
Profilin 1 Antibody
Profilin I Antibody
Profilin1 Antibody
ProfilinI Antibody

Images
Western Blot - Anti-Profilin-1 Antibody from ABclonal (A0639) - Antibody Supply Service
Western blot analysis of extracts of HeLa cells, using PFN1 antibody.

Product Code - A0639
Size Price Quantity
100µl £243
200µl £372

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