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Anti-DUSP6 Antibody

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ABclonal
A0637
Overview
Name: Anti-DUSP6 Antibody
Description: Rabbit polyclonal antibody to DUSP6.
Applications: WB, IF
Dilutions: WB 1:500 - 1:1000, IF 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human DUSP6
Protein Length: 381
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity).
Involvement in Disease: Hypogonadotropic hypogonadism 19 with or without anosmia: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Sequence Similarities: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Cellular Location: Cytoplasm.
UniProt: Q16828
Gene ID: 1848
Synonyms: Dual specificity phosphatase 6 Antibody
Dual specificity phosphatase 6 isoform a Antibody
Dual specificity protein phosphatase 6 Antibody
Dual specificity protein phosphatase PYST1 Antibody
DUS6_HUMAN Antibody
DUSP 6 Antibody
DUSP 6a Antibody
DUSP6a Antibody
HH19 Antibody
MAP kinase phosphatase 3 Antibody
Mitogen activated protein kinase phosphatase 3 Antibody
Mitogen-activated protein kinase phosphatase 3 Antibody
MKP 3 Antibody
MKP-3 Antibody
MKP3 Antibody
PYST 1 Antibody
PYST1 Antibody
Serine/threonine specific protein phosphatase Antibody

Images
Western Blot - Anti-DUSP6 Antibody from ABclonal (A0637) - Antibody Supply Service
Western blot analysis of extracts of HeLa cells, using DUSP6 antibody.

Product Code - A0637
Size Price Quantity
100µl £243
200µl £372

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