|Description:||Rabbit polyclonal antibody to SSB.|
|Immunogen:||Recombinant protein of human SSB|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Background:||The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
|Recommended Dilutions:||WB 1:500 - 1:1000, IHC 1:100 - 1:200|
Target (Information from UniProt)
|Function:||Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).|
|Post-Translational Modification:||Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.|
Western blot analysis of extracts of 293 cell line, using SSB antibody.
Immunohistochemistry of paraffin-embedded human liver cancer using SSB antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human prostate cancer using SSB antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human esophagus using SSB antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using SSB antibody at dilution of 1:100 (40x lens).