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Anti-SSB Antibody

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ABclonal
A0630
Details
Description: Rabbit polyclonal antibody to SSB.
Category: Primary Antibodies
Applications: WB, IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P05455
Gene ID: 6741
Immunogen: Recombinant protein of human SSB
Protein Length: 408
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: La; LARP3
Purification: Affinity purification
Background: The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:1000, IHC 1:100 - 1:200

Target (Information from UniProt)
Function: Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).
Post-Translational Modification: Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.
Cellular Location: Nucleus.

Images
Western Blot - Anti-SSB Antibody from ABclonal (A0630) - Antibody Supply Service
Western blot analysis of extracts of 293 cell line, using SSB antibody.
Immunohistochemistry - Anti-SSB Antibody from ABclonal (A0630) - Antibody Supply Service
Immunohistochemistry of paraffin-embedded human liver cancer using SSB antibody at dilution of 1:100 (40x lens).
Immunohistochemistry - Anti-SSB Antibody from ABclonal (A0630) - Antibody Supply Service
Immunohistochemistry of paraffin-embedded human prostate cancer using SSB antibody at dilution of 1:100 (40x lens).
Immunohistochemistry - Anti-SSB Antibody from ABclonal (A0630) - Antibody Supply Service
Immunohistochemistry of paraffin-embedded human esophagus using SSB antibody at dilution of 1:100 (40x lens).
Immunohistochemistry - Anti-SSB Antibody from ABclonal (A0630) - Antibody Supply Service
Immunohistochemistry of paraffin-embedded human stomach using SSB antibody at dilution of 1:100 (40x lens).

Product Code - A0630
Size Price Quantity
50µl £148
100µl £243
200µl £372

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