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Anti-GAB2 Antibody

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ABclonal
A0619
Overview
Name: Anti-GAB2 Antibody
Description: Rabbit polyclonal antibody to GAB2.
Applications: WB, FC
Dilutions: WB 1:500 - 1:1000, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic Peptide of human GAB2
Protein Length: 676
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Sequence Similarities: Belongs to the GAB family.
Post-Translational Modification: Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.
Cellular Location: Cytoplasm. Cell membrane.
UniProt: Q9UQC2
Gene ID: 9846
Synonyms: GAB 2 Antibody
GAB2 (phospho S159) Antibody
GAB2 (phospho S623) Antibody
GAB2 (phospho Y452) Antibody
GAB2 (phospho Y643) Antibody
GAB2_HUMAN Antibody
Grb 2 associated binder 2 Antibody
GRB 2 associated binding protein 2 Antibody
Grb2 associated binder 2 Antibody
GRB2 associated binder 2 pp100 Antibody
GRB2 associated binding protein 2 Antibody
GRB2-associated binder 2 Antibody
GRB2-associated-binding protein 2 Antibody
Growth factor receptor bound protein 2 associated protein 2 Antibody
Growth factor receptor bound protein 2-associated protein 2 Antibody
KIAA0571 Antibody
p97 Antibody
PH domain containing adaptor molecule p97 Antibody
pp100 Antibody

Images
Western Blot - Anti-GAB2 Antibody from ABclonal (A0619) - Antibody Supply Service
Western blot analysis of extracts of MCF7 cells, using GAB2 antibody.

Product Code - A0619
Size Price Quantity
100µl £243
200µl £372

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