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Anti-TFII-I Antibody

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ABclonal
A0617
Overview
Name: Anti-TFII-I Antibody
Description: Rabbit polyclonal antibody to TFII-I.
Applications: WB, IHC, IF, FC
Dilutions: WB 1:200 - 1:2000, IHC 1:50 - 1:200, IF 1:50 - 1:100, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human GTF2I
Protein Length: 998
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.
Tissue Specificity: Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues.
Sequence Similarities: Belongs to the TFII-I family.
Post-Translational Modification: Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation.
Cellular Location: Cytoplasm. Nucleus.

Colocalizes with BTK in the cytoplasm.
UniProt: P78347
Gene ID: 2969
Synonyms: BAP 135 Antibody
BAP-135 Antibody
BAP135 Antibody
Bruton tyrosine kinase associated protein 135 Antibody
Bruton tyrosine kinase-associated protein 135 Antibody
BTK associated protein Antibody
BTK associated protein 135 Antibody
BTK associated protein 135kD Antibody
BTK-associated protein 135 Antibody
BTKAP 1 Antibody
BTKAP1 Antibody
DIWS Antibody
FLJ38776 Antibody
FLJ56355 Antibody
General transcription factor II i Antibody
General transcription factor II-I Antibody
General transcription factor IIi Antibody
GTF 2I Antibody
Gtf2i Antibody
GTF2I_HUMAN Antibody
GTFII I Antibody
GTFII-I Antibody
IB 291 Antibody
IB291 Antibody
SPIN Antibody
SRF Phox 1 interacting protein Antibody
SRF Phox1 interacting protein Antibody
SRF-Phox1-interacting protein Antibody
TFII I Antibody
TFII I (phospho Y248) Antibody
Transcription factor II I Antibody
WBS Antibody
WBSCR 6 Antibody
WBSCR6 Antibody
Williams Beuren syndrome chromosome region 6 Antibody
Williams Beuren syndrome chromosome region 6 protein Antibody
Williams-Beuren syndrome chromosomal region 6 protein Antibody

Images
Western Blot - Anti-TFII-I Antibody from ABclonal (A0617) - Antibody Supply Service
Western blot analysis of extracts of 293 cells tissue, using GTF2I antibody.

Product Code - A0617
Size Price Quantity
100µl £243
200µl £372

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