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Anti-MSK1 Antibody

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ABclonal
A0614
Overview
Name: Anti-MSK1 Antibody
Description: Rabbit polyclonal antibody to MSK1.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: A synthetic Peptide of human RPS6KA5
Protein Length: 802
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.
Tissue Specificity: Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.
Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Post-Translational Modification: Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain. Phosphorylated at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha. Autophosphorylated at Ser-750, Ser-752 and Ser-758 by the N-terminal kinase domain.
Cellular Location: Nucleus. Cytoplasm.

Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid.
UniProt: O75582
Gene ID: 9252
Synonyms: 90 kDa ribosomal protein S6 kinase 5 Antibody
EC 2.7.11.1 Antibody
KS6A5_HUMAN Antibody
MGC1911 Antibody
Mitogen and stress activated protein kinase 1 Antibody
MSPK1 Antibody
Nuclear Mitogen And Stress Activated Protein Kinase 1 Antibody
Nuclear mitogen- and stress-activated protein kinase 1 Antibody
Ribosomal protein S6 kinase 90kD polypeptide 5 Antibody
Ribosomal protein S6 kinase 90kDa Antibody
Ribosomal protein S6 kinase 90kDa polypeptide 5 Antibody
Ribosomal Protein S6 Kinase Alpha 5 Antibody
Ribosomal protein S6 kinase alpha-5 Antibody
RLPK Antibody
RPS6KA5 Antibody
RSK Like Protein Kinase Antibody
RSK-like protein kinase Antibody
RSKL Antibody
S6K alpha 5 Antibody
S6K-alpha-5 Antibody

Product Code - A0614
Size Price Quantity
100µl £243
200µl £372

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