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Anti-RRM1 Antibody

file icon Datasheet
ABclonal
A0599
Details
Description: Rabbit polyclonal antibody to RRM1.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P23921
Gene ID: 6240
Immunogen: A synthetic peptide of human RRM1
Protein Length: 792
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: R1; RIR1; RR1
Purification: Affinity purification
Background: Ribonucleoside-diphosphate reductase functions as a heterodimer of a large and a small subunits in deoxyribonucleotide synthesis. RRM1 constitutes to the large subunit (R1) of ribonucleotide reductase, and it can either form heterodimer with small subunit RRM or RRM2B(PMID:16376858). RRM1 provides the precursors necessary for DNA synthesis. RRM1 can not be detected in quiescent cells, while its mRNA and protein are present throughout the cell cycle in cycling cells(PMID:8188248). Researches showed that RRM1 is involved in carcinogenesis, tumor progression, and the resistance of non-small-cell lung cancer (NSCLC) to treatment. Low level expression of RRM1 in NSCLC is associated with poor survival(PMID:17314339). This antibody is specific to RRM1.
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:1000

Target (Information from UniProt)
Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Sequence Similarities: Belongs to the ribonucleoside diphosphate reductase large chain family.
Cellular Location: Cytoplasm.

Images
Western Blot - Anti-RRM1 Antibody from ABclonal (A0599) - Antibody Supply Service
Western blot analysis of extracts of HeLa cells tissue, using RRM1 antibody.

Product Code - A0599
Size Price Quantity
100µl £243
200µl £372

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