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Anti-Axin1 Antibody

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ABclonal
A0583
Overview
Name: Anti-Axin1 Antibody
Description: Rabbit polyclonal antibody to Axin1.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:100
Reactivity: Human
Immunogen: A synthetic peptide of human AXIN1
Protein Length: 862
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Tissue Specificity: Ubiquitously expressed.
Involvement in Disease: Hepatocellular carcinoma: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.

Caudal duplication anomaly: A condition characterized by the occurrence of duplications of different organs in the caudal region.
Post-Translational Modification: Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1.
Cellular Location: Cytoplasm. Nucleus. Membrane. Cell membrane.

MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX (PubMed:17210684).
UniProt: O15169
Gene ID: 8312
Synonyms: AI316800 Antibody
AXIN Antibody
Axin 1 Antibody
Axin-1 Antibody
AXIN1_HUMAN Antibody
Axis inhibition protein 1 Antibody
Axis Inhibitor 1 Antibody
Fu Antibody
fused Antibody
Fused, mouse, homolog of Antibody
hAxin Antibody
Kb Antibody
Ki Antibody
kinky Antibody
knobbly Antibody
MGC132911 Antibody
MGC52315 Antibody
PPP1R49 Antibody
Protein Fused Antibody
Protein phosphatase 1 regulatory subunit 49 Antibody

Images
Western Blot - Anti-Axin1 Antibody from ABclonal (A0583) - Antibody Supply Service
Western blot analysis of extracts of Raji cells, using AXIN1 antibody.

Product Code - A0583
Size Price Quantity
100µl £243
200µl £372

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