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Anti-Skp1 Antibody

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ABclonal
A0554
Overview
Name: Anti-Skp1 Antibody
Description: Rabbit polyclonal antibody to Skp1.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: A synthetic peptide of human SKP1
Protein Length: 163
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.
Sequence Similarities: Belongs to the SKP1 family.
UniProt: P63208
Gene ID: 6500
Synonyms: Cyclin A/CDK2 associated p19 Antibody
Cyclin A/CDK2 associated protein p19 Antibody
Cyclin-A/CDK2-associated protein p19 Antibody
EMC19 Antibody
MGC34403 Antibody
OCP 2 Antibody
OCP II Antibody
OCP II protein Antibody
OCP-2 Antibody
OCP-II Antibody
OCP2 Antibody
OCPII Antibody
Organ of Corti protein 2 Antibody
Organ of Corti protein II Antibody
OTTHUMP00000159379 Antibody
OTTHUMP00000159380 Antibody
OTTHUMP00000228275 Antibody
OTTHUMP00000228276 Antibody
OTTHUMP00000228278 Antibody
OTTHUMP00000228279 Antibody
OTTHUMP00000228281 Antibody
p19A Antibody
p19skp1 Antibody
RNA polymerase II elongation factor like protein Antibody
RNA polymerase II elongation factor like protein OCP2 Antibody
RNA polymerase II elongation factor-like protein Antibody
S phase kinase associated protein 1 Antibody
S phase kinase associated protein 1A Antibody
S phase kinase associated protein 1A p19A Antibody
S-phase kinase-associated protein 1 Antibody
SIII Antibody
Skp 1 Antibody
SKP 1A Antibody
SKP1A Antibody
SKP1_HUMAN Antibody
TCEB1L Antibody
Transcription elongation factor B Antibody
Transcription Elongation Factor B 1 like Antibody
Transcription elongation factor B SIII polypeptide 1 like Antibody

Images
Western Blot - Anti-Skp1 Antibody from ABclonal (A0554) - Antibody Supply Service
Western blot analysis of extracts of HeLa cell tissue, using SKP1 antibody.

Product Code - A0554
Size Price Quantity
100µl £243
200µl £372

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