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Anti-TRX Antibody

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ABclonal
A0537
Overview
Name: Anti-TRX Antibody
Description: Rabbit polyclonal antibody to TRX.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200
Reactivity: Human
Immunogen: A synthetic peptide of human TXN
Protein Length: 105
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Sequence Similarities: Belongs to the thioredoxin family.
Post-Translational Modification: In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins.
Cellular Location: Nucleus. Cytoplasm. Secreted.

Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947).
UniProt: P10599
Gene ID: 7295
Synonyms: ADF Antibody
ArPIKfyve Antibody
ATL derived factor Antibody
ATL-derived factor Antibody
DKFZp686B1993 Antibody
FLJ10305 Antibody
FLJ36622 Antibody
FLJ46582 Antibody
MGC149815 Antibody
MGC149816 Antibody
MGC61975 Antibody
OTTHUMP00000174908 Antibody
Protein VAC14 homolog Antibody
SASP Antibody
Surface associated sulphydryl protein Antibody
Surface-associated sulphydryl protein Antibody
Tax1 (human T cell leukemia virus type I) binding protein 1 Antibody
Tax1 (human T cell leukemia virus type I) binding protein 2 Antibody
Tax1 binding protein 2 Antibody
Tax1-binding protein 2 Antibody
TAX1BP2 Antibody
testicular tissue protein Li 199 Antibody
Thioredoxin Antibody
Thioredoxin / TRX Antibody
thioredoxin delta 3 Antibody
THIO_HUMAN Antibody
TRDX Antibody
TRX 1 Antibody
TRX1 Antibody
TXN Antibody
TXN delta 3 Antibody
TXN protein Antibody
VAC 14 Antibody
VAC14 Antibody
Vac14 homolog Antibody
Vac14 homolog (S. cerevisiae) Antibody
VAC14_HUMAN Antibody
zgc:92903 Antibody

Images
Western Blot - Anti-TRX Antibody from ABclonal (A0537) - Antibody Supply Service
Western blot analysis of extracts of Jurkat cells tissue, using TXN antibody.

Product Code - A0537
Size Price Quantity
100µl £243
200µl £372

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