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Anti-CDC25B Antibody

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ABclonal
A0534
Overview
Name: Anti-CDC25B Antibody
Description: Rabbit polyclonal antibody to CDC25B.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: Recombinant protein of human CDC25B
Protein Length: 580
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
Sequence Similarities: Belongs to the MPI phosphatase family.
Post-Translational Modification: Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.
Cellular Location: Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle pole.
UniProt: P30305
Gene ID: 994
Synonyms: AI604853 Antibody
Cdc 25B Antibody
Cdc25B (phospho S149) Antibody
Cdc25B (phospho S187) Antibody
Cdc25B (phospho S323) Antibody
Cdc25B (phospho S353) Antibody
CDC25HU2 Antibody
Cdc25m2 Antibody
Cell division cycle 25 homolog B Antibody
Cell division cycle 25B Antibody
Cell division cycle 25B isoform 1 Antibody
Cell division cycle 25B isoform 2 Antibody
Cell division cycle 25B isoform 3 Antibody
Cell division cycle 25B isoform 4 Antibody
Cell division cycle 25B isoform 5 Antibody
Dual specificity phosphatase Cdc25B Antibody
EC 3.1.3.48 Antibody
M phase inducer phosphatase 2 Antibody
M-phase inducer phosphatase 2 Antibody
MPIP2_HUMAN Antibody

Images
Western Blot - Anti-CDC25B Antibody from ABclonal (A0534) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using CDC25B antibody.

Product Code - A0534
Size Price Quantity
50µl £148
100µl £243
200µl £372

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