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Anti-Axl Antibody

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Name: Anti-Axl Antibody
Description: Rabbit polyclonal antibody to Axl.
Applications: WB, IHC, FC
Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:100, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human AXL
Protein Length: 894
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
Tissue Specificity: Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Post-Translational Modification: Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion.
Cellular Location: Cell membrane.
UniProt: P30530
Gene ID: 558
Synonyms: Adhesion related kinase Antibody
AI323647 Antibody
Ark Antibody
AXL oncogene Antibody
AXL receptor tyrosine kinase Antibody
AXL transforming gene Antibody
AXL transforming sequence/gene Antibody
EC Antibody
JTK11 Antibody
Oncogene AXL Antibody
Tyro7 Antibody
Tyrosine protein kinase receptor UFO Antibody
Tyrosine-protein kinase receptor UFO Antibody
UFO Antibody
UFO_HUMAN Antibody

Western Blot - Anti-Axl Antibody from ABclonal (A0532) - Antibody Supply Service
Western blot analysis of extracts of HepG2 cell line, using AXL antibody.

Product Code - A0532
Size Price Quantity
100µl £243
200µl £372

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