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Anti-PAK2 Antibody

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ABclonal
A0518
Overview
Name: Anti-PAK2 Antibody
Description: Rabbit polyclonal antibody to PAK2.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200
Reactivity: Human
Immunogen: A synthetic peptide of human PAK2
Protein Length: 524
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.
Tissue Specificity: Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.
Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Post-Translational Modification: Full length PAK2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated, with PAK-2p27 being phosphorylated on serine and PAK-2p34 on threonine residues, respectively. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate.
Cellular Location: Cytoplasm.

MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.
UniProt: Q13177
Gene ID: 5062
Synonyms: Alpha PAK Antibody
Beta PAK Antibody
bPAK Antibody
C-t-PAK2 Antibody
Cardiolipin activated protein kinase Pak2 Antibody
CB422 Antibody
CDKN1A Antibody
EC 2.7.11.1 Antibody
Gamma PAK Antibody
Gamma-PAK Antibody
hPAK3 Antibody
hPAK65 Antibody
Kinase Antibody
MGC150606 Antibody
MGC71074 Antibody
MRX30 Antibody
MRX47 Antibody
Oligophrenin 3 Antibody
OPHN3 Antibody
P21 (CDKN1A) activated kinase 2 Antibody
P21 (CDKN1A) activated kinase 3 Antibody
p21 (CDKN1A)-activated kinase 2a Antibody
p21 activated kinase 1 Antibody
p21 activated kinase 2 Antibody
p21 activated kinase 3 Antibody
P21 protein (Cdc42/Rac) activated kinase 1 Antibody
P21 protein (Cdc42/Rac) activated kinase 2 Antibody
P21 protein (Cdc42/Rac) activated kinase 3 Antibody
p21 protein (Cdc42/Rac)-activated kinase 2 Antibody
p21 protein Cdc42 Rac activated kinase 2 Antibody
p21-activated kinase 2 Antibody
p21-activated kinase, 65-KD Antibody
p21-activated protein kinase I Antibody
P21/Cdc42/Rac1 activated kinase 1 (STE20 homolog, yeast) Antibody
P21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related) Antibody
p21CDKN1A activated kinase 2 Antibody
p27 Antibody
p34 Antibody
P58 Antibody
P65 PAK Antibody
p65PAK Antibody
PAK 2 Antibody
PAK 3 Antibody
PAK-2 Antibody
PAK-2p34 Antibody
PAK1 Antibody
PAK1 + PAK2 + PAK3 Antibody
PAK1 + PAK2 + PAK3 (phospho S141) Antibody
PAK1 + PAK2 + PAK3 (phospho S144 + S141 + S139) Antibody
PAK1 + PAK2 + PAK3 (phospho T402) Antibody
PAK1 + PAK2 + PAK3 (phospho T423 + T402 + T421) Antibody
PAK1 + PAK2 + PAK3 (phospho T423) Antibody
PAK2 (phospho S192) Antibody
PAK2 (phospho S197) Antibody
PAK2 (phospho S20) Antibody
PAK2_HUMAN Antibody
PAK3 Antibody
PAK3beta Antibody
PAK65 Antibody
PAKalpha Antibody
PAKgamma Antibody
PKN gamma Antibody
PKN2 Antibody
PKN2_HUMAN Antibody
PRK2 Antibody
PRKCL2 Antibody
PRO2042 Antibody
Protein kinase C like 2 Antibody
Protein kinase C related kinase 2 Antibody
Protein kinase C-like 2 Antibody
Protein kinase N2 Antibody
Protein-kinase C-related kinase 2 Antibody
S6 H4 kinase Antibody
S6/H4 kinase Antibody
Serine threonine protein kinase PAK 2 Antibody
Serine/threonine protein kinase PAK 1 Antibody
Serine/threonine protein kinase PAK 2 Antibody
Serine/threonine protein kinase PAK 3 Antibody
Serine/threonine protein kinase PAK1 Antibody
Serine/threonine protein kinase PAK2 Antibody
Serine/threonine protein kinase PAK3 Antibody
Serine/threonine-protein kinase N2 Antibody
STE20 homolog, yeast Antibody

Images
Western Blot - Anti-PAK2 Antibody from ABclonal (A0518) - Antibody Supply Service
Western blot analysis of extracts of HeLa cell line, using PAK2 antibody.

Product Code - A0518
Size Price Quantity
100µl £243
200µl £372

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