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Anti-RAC2 Antibody

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ABclonal
A0509
Details
Description: Rabbit polyclonal antibody to RAC2.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P15153
Gene ID: 5880
Immunogen: A synthetic peptide of human RAC2
Protein Length: 192
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: Gx; EN-7; HSPC022; p21-Rac2
Purification: Affinity purification
Background: RAC2, also named as GX, belongs to the small GTPase superfamily and Rho family. RAC2 is a plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. RAC2 augments the production of reactive oxygen species (ROS) by NADPH oxidase. Defects in RAC2 are the cause of neutrophil immunodeficiency syndrome. The antibody is specific to RAC2.
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:1000, IF 1:20 - 1:50

Target (Information from UniProt)
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Tissue Specificity: Hematopoietic specific.
Involvement in Disease: Neutrophil immunodeficiency syndrome: An immunodeficiency syndrome due to defective neutrophils. Affected individuals present with leukocytosis, neutrophilia, severe recurrent bacterial infections and poor wound healing.
Sequence Similarities: Belongs to the small GTPase superfamily. Rho family.
Post-Translational Modification: (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly.
Cellular Location: Cytoplasm.

Membrane-associated when activated.

Images
Western Blot - Anti-RAC2 Antibody from ABclonal (A0509) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using RAC2 antibody.

Product Code - A0509
Size Price Quantity
100µl £243
200µl £372

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