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Anti-CD130 Antibody

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ABclonal
A0469
Overview
Name: Anti-CD130 Antibody
Description: Rabbit polyclonal antibody to CD130.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:100
Reactivity: Human
Immunogen: A synthetic peptide of human IL6ST
Protein Length: 918
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
Tissue Specificity: Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).
Sequence Similarities: Belongs to the type I cytokine receptor family. Type 2 subfamily.
Post-Translational Modification: Phosphorylation of Ser-782 down-regulates cell surface expression.
Cellular Location: Cell membrane.
UniProt: P40189
Gene ID: 3572
Synonyms: CD130 (gp130) Antibody
CD130 antigen Antibody
CDw130 Antibody
gp130 Antibody
GP130 RAPS Antibody
IL 6R beta Antibody
IL-6 receptor subunit beta Antibody
IL-6R subunit beta Antibody
IL-6R-beta Antibody
IL-6RB Antibody
IL6 ST Antibody
IL6RB_HUMAN Antibody
IL6ST Antibody
Interleukin 6 receptor subunit beta Antibody
Interleukin receptor beta chain Antibody
Interleukin-6 receptor subunit beta Antibody
Interleukin-6 signal transducer Antibody
Membrane glycoprotein 130 Antibody
Membrane glycoprotein gp130 Antibody
Oncostatin M receptor Antibody
Oncostatin M receptor alpha subunit Antibody
Oncostatin-M receptor subunit alpha Antibody

Images
Western Blot - Anti-CD130 Antibody from ABclonal (A0469) - Antibody Supply Service
Western blot analysis of extracts of MDA-MB231 cell lines, using IL6ST antibody.

Product Code - A0469
Size Price Quantity
100µl £243
200µl £372

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