|Description:||Mouse monoclonal antibody to γ-Catenin.|
|Immunogen:||A synthetic peptide of human JUP|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonyms:||DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12|
|Background:||This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.|
|Storage:||Store at 4℃. Avoid freeze / thaw cycles.|
|Recommended Dilutions:||WB 1:500 - 1:1000|
Target (Information from UniProt)
|Function:||Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).|
|Involvement in Disease:||Naxos disease: An autosomal recessive disorder characterized by the association of diffuse non-epidermolytic palmoplantar keratoderma with woolly hair and cardiac abnormalities such as dilated cardiomyopathy and arrhythmogenic right ventricular dysplasia.
Arrhythmogenic right ventricular dysplasia, familial, 12: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
|Sequence Similarities:||Belongs to the beta-catenin family.|
|Post-Translational Modification:||May be phosphorylated by FER.|
|Cellular Location:||Cell junction > Adherens junction. Cell junction > Desmosome. Cytoplasm > Cytoskeleton. Membrane.
Cytoplasmic in a soluble and membrane-associated form.
Western blot analysis of extracts of NCI-H292 cells, using JUP antibody.