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Anti-XRCC1 Antibody

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ABclonal
A0443
Details
Description: Mouse monoclonal antibody to XRCC1.
Category: Primary Antibodies
Applications: WB
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Reactivity: Human
UniProt: P18887
Gene ID: 7515
Immunogen: Recombinant protein of human XRCC1
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: XRCC1; RCC; DNA repair protein XRCC1; X-ray repair cross-complementing protein 1
Purification: Affinity purification
Background: The X-ray repair cross complementing protein 1 (XRCC1) is a DNA repair protein important in both single strand break repair and base excision repair following damage from ionizing radiation and alkylating agents (1). XRCC1 acts as a scaffold protein to coordinate DNA abasic site repair through interaction with several other repair proteins (2). At least eight XRCC1 protein partners have been identified, including the polynucleotide kinase PNK (3), DNA ligase III (4,5), poly (ADP-ribose) polymerase (6), and PCNA (7). Mutations and polymorphisms in the XRCC1 gene serve as diagnostic markers and are associated with elevated risk of various forms of cancers (8).
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000

Target (Information from UniProt)
Function: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
Post-Translational Modification: Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
Cellular Location: Nucleus.

Accumulates at sites of DNA damage.

Images
Western Blot - Anti-XRCC1 Antibody from ABclonal (A0443) - Antibody Supply Service
Western blot analysis of extracts of various cells, using XRCC1 antibody.

Product Code - A0443
Size Price Quantity
50µl £199
100µl £307
200µl £452

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