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Anti-Histone Deacetylase 1 Antibody

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ABclonal
A0421
Overview
Name: Anti-Histone Deacetylase 1 Antibody
Description: Mouse monoclonal antibody to Histone Deacetylase 1.
Applications: WB
Dilutions: WB 1:200 - 1:2000
Reactivity: Human
Immunogen: A synthetic peptide of human HDAC1
Protein Length: 482
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
Tissue Specificity: Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
Sequence Similarities: Belongs to the histone deacetylase family. HD type 1 subfamily.
Post-Translational Modification: Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
Cellular Location: Nucleus.
UniProt: Q13547
Gene ID: 3065
Synonyms: DKFZp686H12203 Antibody
GON 10 Antibody
HD1 Antibody
HDAC 1 Antibody
HDAC1 Antibody
HDAC1_HUMAN Antibody
Reduced potassium dependency yeast homolog like 1 Antibody
RPD3 Antibody
RPD3L1 Antibody

Images
Western Blot - Anti-Histone Deacetylase 1 Antibody from ABclonal (A0421) - Antibody Supply Service
Western blot analysis of extracts of HepG2 cell line, using HDAC1 antibody.

Product Code - A0421
Size Price Quantity
100µl £243
200µl £372

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