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Anti-AML1 Antibody

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Name: Anti-AML1 Antibody
Description: Rabbit polyclonal antibody to AML1.
Applications: WB, IHC, IF, FC
Dilutions: WB 1:500 - 1:1000, IHC 1:20- 1:50, IF 1:20- 1:50, FC 1:20- 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human RUNX1
Protein Length: 453
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532).
Tissue Specificity: Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
Involvement in Disease: Familial platelet disorder with associated myeloid malignancy: Autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia.
Post-Translational Modification: Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with KAT6A.
Cellular Location: Nucleus.
UniProt: Q01196
Gene ID: 861
Synonyms: Acute myeloid leukemia 1 Antibody
Acute myeloid leukemia 1 protein Antibody
alpha subunit core binding factor Antibody
AML 1 Antibody
AML1 EVI 1 Antibody
AML1 EVI 1 fusion protein Antibody
Aml1 oncogene Antibody
AMLCR 1 Antibody
AMLCR1 Antibody
CBF alpha 2 Antibody
CBF-alpha-2 Antibody
CBFA 2 Antibody
CBFA2 Antibody
Core binding factor alpha 2 subunit Antibody
Core binding factor runt domain alpha subunit 2 Antibody
Core-binding factor subunit alpha-2 Antibody
EVI 1 Antibody
EVI1 Antibody
HGNC Antibody
Oncogene AML 1 Antibody
Oncogene AML-1 Antibody
OTTHUMP00000108696 Antibody
OTTHUMP00000108697 Antibody
OTTHUMP00000108699 Antibody
OTTHUMP00000108700 Antibody
OTTHUMP00000108702 Antibody
PEA2 alpha B Antibody
PEA2-alpha B Antibody
PEBP2 alpha B Antibody
PEBP2-alpha B Antibody
PEBP2A2 Antibody
PEBP2aB Antibody
Polyomavirus enhancer binding protein 2 alpha B subunit Antibody
Polyomavirus enhancer-binding protein 2 alpha B subunit Antibody
Run1 Antibody
Runt related transcription factor 1 Antibody
Runt-related transcription factor 1 Antibody
RUNX 1 Antibody
Runx1 Antibody
RUNX1 / AML1 Antibody
RUNX1 / AML1 (phospho S276) Antibody
RUNX1 / AML1 (phospho S303) Antibody
RUNX1 / AML1 (phospho S435) Antibody
RUNX1_HUMAN Antibody
SL3 3 enhancer factor 1 alpha B subunit Antibody
SL3-3 enhancer factor 1 alpha B subunit Antibody
SL3/AKV core binding factor alpha B subunit Antibody
SL3/AKV core-binding factor alpha B subunit Antibody

Western Blot - Anti-AML1 Antibody from ABclonal (A0399) - Antibody Supply Service
Western blot analysis of extracts of U937 cells, using RUNX1 antibody.

Product Code - A0399
Size Price Quantity
100µl £243
200µl £372

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