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Anti-XIAP Antibody

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ABclonal
A0383
Overview
Name: Anti-XIAP Antibody
Description: Rabbit polyclonal antibody to XIAP.
Applications: WB, ICC
Dilutions: WB 1:1000 - 1:2000, ICC 1:50 - 1:100
Reactivity: Human
Immunogen: Recombinant protein of human XIAP
Protein Length: 497
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.
Tissue Specificity: Ubiquitous, except peripheral blood leukocytes.
Involvement in Disease: Lymphoproliferative syndrome, X-linked, 2: A rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
Sequence Similarities: Belongs to the IAP family.
Post-Translational Modification: S-Nitrosylation down-regulates its E3 ubiquitin-protein ligase activity.
Cellular Location: Cytoplasm. Nucleus.

TLE3 promotes its nuclear localization.
UniProt: P98170
Gene ID: 331
Synonyms: AP 13 Antibody
API3 Antibody
Apoptosis Inhibitor 3 Antibody
Baculoviral IAP repeat containing 4 Antibody
Baculoviral IAP Repeat Containing Protein 4 Antibody
Baculoviral IAP repeat-containing protein 4 Antibody
BIRC 4 Antibody
BIRC4 Antibody
E3 ubiquitin-protein ligase XIAP Antibody
hIAP-3 Antibody
hIAP3 Antibody
HILP Antibody
IAP 3 Antibody
IAP like protein Antibody
IAP-3 Antibody
IAP-like protein Antibody
IAP3 Antibody
ILP Antibody
ILP 1 Antibody
ILP1 Antibody
Inhibitor of apoptosis protein 3 Antibody
Inhibitor of Apoptosis X Linked Antibody
Mammalian IAP Homologue A Antibody
MIHA Antibody
X linked IAP Antibody
X linked inhibitor of apoptosis Antibody
X linked inhibitor of apoptosis E3 ubiquitin protein ligase Antibody
X linked inhibitor of apoptosis protein Antibody
X-linked IAP Antibody
X-linked inhibitor of apoptosis protein Antibody
XIAP (phospho S87) Antibody
XIAP_HUMAN Antibody
XLP2 Antibody

Images
Western Blot - Anti-XIAP Antibody from ABclonal (A0383) - Antibody Supply Service
Western blot analysis of Hepg2 cell lysate using XIAP antibody.

Product Code - A0383
Size Price Quantity
50µl £243
100µl £372
200µl £565

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