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Anti-Cyclin B1 Antibody

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Description: Rabbit polyclonal antibody to Cyclin B1.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P14635
Gene ID: 891
Immunogen: A synthetic peptide of human CCNB1
Protein Length: 433
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: CCNB
Purification: Affinity purification
Background: Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase of the cell cycle. The different transcripts result from the use of alternate transcription initiation sites. The antibody is specific to CCNB1.
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000

Target (Information from UniProt)
Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Sequence Similarities: Belongs to the cyclin family. Cyclin AB subfamily.
Post-Translational Modification: Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
Cellular Location: Cytoplasm. Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.

Western Blot - Anti-Cyclin B1 Antibody from ABclonal (A0381) - Antibody Supply Service
Western blot analysis of extracts of HepG2 cell line, using CCNB1 antibody.

Product Code - A0381
Size Price Quantity
100µl £243
200µl £372

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