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Anti-CD45 Antibody

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ABclonal
A0371
Overview
Name: Anti-CD45 Antibody
Description: Rabbit polyclonal antibody to CD45.
Applications: WB, IHC, FC
Dilutions: WB 1:200 - 1:500, IHC 1:50 - 1:100, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human PTPRC
Protein Length: 1304
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Involvement in Disease: Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.

Multiple sclerosis: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
Sequence Similarities: Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Post-Translational Modification: Heavily N- and O-glycosylated.
Cellular Location: Membrane. Membrane raft.

Colocalized with DPP4 in membrane rafts.
UniProt: P08575
Gene ID: 5788
Synonyms: B220 Antibody
CD 45 Antibody
CD45 (phospho S1007) Antibody
CD45 antigen Antibody
CD45.1 Antibody
CD45R Antibody
CD45RA Antibody
CD45RB Antibody
CD45RC Antibody
CD45RO Antibody
EC 3.1.3.48 Antibody
Glycoprotein Antibody
GP180 Antibody
L CA Antibody
L-CA Antibody
LCA Antibody
Leukocyte common antigen Antibody
Leukocyte common antigen precursor Antibody
loc Antibody
LY 5 Antibody
Ly-5 Antibody
LY5 Antibody
Ly5, homolog of Antibody
Lymphocyte antigen 5 Antibody
Lyt-4 Antibody
Lyt4 Antibody
OTTHUMP00000033813 Antibody
OTTHUMP00000033816 Antibody
OTTHUMP00000033817 Antibody
OTTHUMP00000038574 Antibody
Protein tyrosine phosphatase receptor type C Antibody
Protein tyrosine phosphatase receptor type c polypeptide Antibody
protein tyrosine phosphatase, receptor type, C Antibody
Protein tyrosine phosphatase, receptor type, c polypeptide Antibody
Ptprc Antibody
PTPRC_HUMAN Antibody
Receptor type tyrosine protein phosphatase C Antibody
Receptor-type tyrosine-protein phosphatase C Antibody
RT7 Antibody
T200 Antibody
T200 glycoprotein Antibody
T200 leukocyte common antigen Antibody

Images
Western Blot - Anti-CD45 Antibody from ABclonal (A0371) - Antibody Supply Service
Western blot analysis of Jurkat cell lysate using PTPRC antibody.

Product Code - A0371
Size Price Quantity
100µl £243
200µl £372

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