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Anti-GSTP1 Antibody

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ABclonal
A0348
Details
Description: Rabbit polyclonal antibody to GSTP1.
Category: Primary Antibodies
Applications: WB, IHC, IF, FC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P09211
Gene ID: 2950
Immunogen: A synthetic peptide of human GSTP1
Protein Length: 210
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: GSTP1; DFN7; FAEES3; GST3; PI
Purification: Affinity purification
Background: Glutathione S-transferases (GSTs) are a family of isoenzymes that detoxify electrophiles through conjugation to thiol-reduced glutathione (GSH). Thus, they are critical in protecting cells from toxins (drugs, pesticides, carcinogens) and oxidative stress (1). Eight isoforms of cytosolic-soluble GSTs (α, κ, μ, π, σ, θ, ζ, and ω) are identified, while only GST-α, -μ, and -π are described in the central nervous system (2). GSTP1 (GSTπ) is overexpressed in early stages of carcinogenesis and can be used as a neoplastic marker in tumor tissues (3). GSTP1 directly inhibits TRAF2 and JNK but not NF-κB (4,5). Corresponding GSTP1 gene polymorphisms affect substrate selectivity and stability, and the oxidative milieu in dopaminergic neurons, which increases the susceptibility to Parkinson’s disease (6).
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:1000, IHC 1:20 - 1:50, IF 1:20 - 1:50, FC 1:20 - 1:50

Target (Information from UniProt)
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Sequence Similarities: Belongs to the GST superfamily. Pi family.
Cellular Location: Cytoplasm. Mitochondrion. Nucleus.

The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.

Images
Western Blot - Anti-GSTP1 Antibody from ABclonal (A0348) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using GSTP1 antibody.

Product Code - A0348
Size Price Quantity
100µl £243
200µl £372

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