|Description:||Rabbit polyclonal antibody to CD79A.|
|Dilutions:||WB 1:500 - 1:1000|
|Immunogen:||Recombinant protein of human CD79A|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.|
|Involvement in Disease:||Agammaglobulinemia 3, autosomal recessive: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.|
|Post-Translational Modification:||Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.|
|Cellular Location:||Cell membrane.
Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
|Synonyms:||B lymphocyte-specific MB1 protein Antibody
B-cell antigen receptor complex-associated protein alpha chain Antibody
CD 79a Antibody
CD79A antigen Antibody
CD79a antigen (immunoglobulin-associated alpha) Antibody
CD79a molecule, immunoglobulin-associated alpha Antibody
Ig alpha Antibody
Immunoglobulin-associated alpha Antibody
MB-1 membrane glycoprotein Antibody
Membrane-bound immunoglobulin-associated protein Antibody
Surface IgM-associated protein Antibody
Western blot analysis of extract of various cells, using CD79A antibody.