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Anti-CD40LG Antibody

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ABclonal
A0327
Overview
Name: Anti-CD40LG Antibody
Description: Rabbit polyclonal antibody to CD40LG.
Applications: WB, IHC, IF
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:50 - 1:200
Reactivity: Human
Immunogen: Recombinant protein of human CD40LG
Protein Length: 261
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity).
Tissue Specificity: Specifically expressed on activated CD4+ T-lymphocytes.
Involvement in Disease: X-linked immunodeficiency with hyper-IgM 1: Immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
Sequence Similarities: Belongs to the tumor necrosis factor family.
Post-Translational Modification: The soluble form derives from the membrane form by proteolytic processing.
Cellular Location: Cell membrane. Cell surface.
UniProt: P29965
Gene ID: 959
Synonyms: CD 40L Antibody
CD154 Antibody
CD40 antigen ligand Antibody
CD40 ligand Antibody
CD40 ligand, soluble form Antibody
CD40-L Antibody
CD40L Antibody
CD40L_HUMAN Antibody
gp39 Antibody
hCD40L Antibody
HIGM1 Antibody
IGM Antibody
IMD3 Antibody
T B cell activating molecule Antibody
T BAM Antibody
T-cell antigen Gp39 Antibody
TNF-related activation protein Antibody
TNFSF5 Antibody
TrAP Antibody
Tumor necrosis factor (ligand) superfamily member 5 Antibody
Tumor necrosis factor ligand superfamily member 5 Antibody

Images
Western Blot - Anti-CD40LG Antibody from ABclonal (A0327) - Antibody Supply Service
Western blot analysis of extracts of various cells, using CD40LG antibody.
Immunofluorescence - Anti-CD40LG Antibody from ABclonal (A0327) - Antibody Supply Service
Immunofluorescence analysis of U20S cell using CD40LG antibody. Blue: DAPI for nuclear staining.

Product Code - A0327
Size Price Quantity
50µl £148
100µl £243
200µl £372

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