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Anti-IL2 Antibody

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ABclonal
A0302
Details
Description: Rabbit polyclonal antibody to IL2.
Category: Primary Antibodies
Applications: WB, IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P60568
Gene ID: 3558
Immunogen: Recombinant protein of human IL2
Protein Length: 153
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: IL2; IL-2; TCGF; lymphokine
Purification: Affinity purification
Background: IL-2 is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation (1,2). IL-2 also promotes peripheral development of Treg cells (4, 5). Conversely, IL-2 is involved in activation induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells (3). The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Rα, IL-2Rβ and the common gamma chain, γc (1,2). IL-2 Rα binds exclusively to IL-2 with low affinity and increases binding affinity of the whole receptor complex including IL-2Rβ and γc subunits. IL-2Rβ is also used by IL-15 (1,2). The common γc is used by other cytokines including IL-4, IL-7, IL-9, IL-15, and IL-21 (1,2). Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5 and the PI3K/Akt pathways (1,2).
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:100

Target (Information from UniProt)
Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Sequence Similarities: Belongs to the IL-2 family.
Cellular Location: Secreted.

Images
Western Blot - Anti-IL2 Antibody from ABclonal (A0302) - Antibody Supply Service
Western blot analysis of extract of various cells, using IL2 antibody.
Immunohistochemistry - Anti-IL2 Antibody from ABclonal (A0302) - Antibody Supply Service
Immunohistochemistry of paraffin-embedded human liver cancer using IL2 antibody at dilution of 1:100 (40x lens).

Product Code - A0302
Size Price Quantity
50µl £148
100µl £243
200µl £372

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