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Anti-RYR2 Antibody

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ABclonal
A0298
Overview
Name: Anti-RYR2 Antibody
Description: Rabbit polyclonal antibody to RYR2.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: A synthetic peptide of human RYR2
Protein Length: 4967
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
Tissue Specificity: Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta.
Involvement in Disease: Arrhythmogenic right ventricular dysplasia, familial, 2: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.

Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy: An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT1 inheritance is autosomal dominant.
Sequence Similarities: Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily.
Post-Translational Modification: Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels.
Cellular Location: Sarcoplasmic reticulum membrane. Membrane. Sarcoplasmic reticulum.

The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic.
UniProt: Q92736
Gene ID: 6262
Synonyms: Arrhythmogenic right ventricular dysplasia 2 Antibody
ARVC2 Antibody
ARVD2 Antibody
Brain ryanodine receptor calcium release channel Antibody
Brain type ryanodine receptor Antibody
Cardiac muscle ryanodine receptor Antibody
Cardiac muscle ryanodine receptor calcium release channel Antibody
Cardiac muscle ryanodine receptor-calcium release channel Antibody
Cardiac muscle type ryanodine receptor Antibody
CCO Antibody
Central core disease of muscle Antibody
HBRR Antibody
hRYR 2 Antibody
hRYR-2 Antibody
hRYR2 Antibody
MHS Antibody
MHS1 Antibody
Ryanodine Receptor Antibody
Ryanodine receptor 1 Antibody
Ryanodine receptor 1 (skeletal) Antibody
Ryanodine receptor 2 Antibody
ryanodine receptor 2 (cardiac) Antibody
Ryanodine receptor 2 (phospho S2808) Antibody
Ryanodine receptor 3 Antibody
Ryanodine receptor type1 Antibody
RYDR Antibody
RyR Antibody
RYR 1 Antibody
RYR 2 Antibody
RYR 3 Antibody
RYR-1 Antibody
RYR-2 Antibody
RyR1 Antibody
RYR1_HUMAN Antibody
RYR2_HUMAN Antibody
RYR3 Antibody
Sarcoplasmic reticulum calcium release channel Antibody
Skeletal muscle calcium release channel Antibody
Skeletal muscle ryanodine receptor Antibody
Skeletal muscle type ryanodine receptor Antibody
Skeletal muscle-type ryanodine receptor Antibody
SKRR Antibody
Type 1 like ryanodine receptor Antibody
Type 1 ryanodine receptor Antibody
Type 2 ryanodine receptor Antibody
VTSIP Antibody

Images
Western Blot - Anti-RYR2 Antibody from ABclonal (A0298) - Antibody Supply Service
Western blot analysis of extracts of Mouse heart cells,using RYR2 antibody.

Product Code - A0298
Size Price Quantity
50µl £148
100µl £243
200µl £372

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