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Anti-TGF-β Antibody

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ABclonal
A0291
Overview
Name: Anti-TGF-β Antibody
Description: Mouse monoclonal antibody to TGF-β.
Applications: WB, IHC, FC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200, FC 1:50 - 1:200
Reactivity: Human
Immunogen: Recombinant protein of human TGFB1
Protein Length: 390
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292).
Tissue Specificity: Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.
Involvement in Disease: Camurati-Engelmann disease: An autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.
Sequence Similarities: Belongs to the TGF-beta family.
Post-Translational Modification: Glycosylated.
Cellular Location: Secreted > Extracellular space > Extracellular matrix.
UniProt: P01137
Gene ID: 7040

Images
Western Blot - Anti-TGF-β Antibody from ABclonal (A0291) - Antibody Supply Service
Western blot analysis of extracts of A549 cell and HepG2 cell tissue, using TGFB1 antibody.

Product Code - A0291
Size Price Quantity
50µl £199
100µl £307
200µl £452

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