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Anti-p14 ARF (P16) Antibody

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ABclonal
A0262
Overview
Name: Anti-p14 ARF (P16) Antibody
Description: Rabbit polyclonal antibody to p14 ARF (P16) .
Applications: WB, IHC, IF
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:50 - 1:200
Reactivity: Human
Immunogen: A synthetic peptide of human CDKN2A
Protein Length: 156
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Tissue Specificity: Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
Involvement in Disease: Melanoma, cutaneous malignant 2: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.

Familial atypical multiple mole melanoma-pancreatic carcinoma syndrome: An inherited cancer predisposition syndrome characterized by an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer.

Melanoma-astrocytoma syndrome: Characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma.
Sequence Similarities: Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Post-Translational Modification: Phosphorylation seems to increase interaction with CDK4.
Cellular Location: Cytoplasm. Nucleus.
UniProt: P42771
Gene ID: 1029

Images
Western Blot - Anti-p14 ARF(P16) Antibody from ABclonal (A0262) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using CDKN2A antibody.
Immunofluorescence - Anti-p14 ARF(P16) Antibody from ABclonal (A0262) - Antibody Supply Service
Immunofluorescence analysis of A549 cells using CDKN2A antibody.

Product Code - A0262
Size Price Quantity
50µl £148
100µl £243
200µl £372

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