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Anti-NGF Antibody

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ABclonal
A0258
Details
Description: Rabbit polyclonal antibody to NGF.
Category: Primary Antibodies
Applications: WB, IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P01138
Gene ID: 4803
Immunogen: Recombinant protein of human NGF
Protein Length: 241
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: NGF; Beta-NGF; HSAN5; MGC161426; MGC161428; NGFB; proNGF
Purification: Affinity purification
Background: Nerve growth factor (NGF) is a small, secreted protein and member of the neurotrophin family of growth factors that promote neuronal cell survival and differentiation (1). Producing cells release NGF that bind and activate TrkA high affinity receptors to mediate NGF-driven signaling. NGF also binds to a low affinity p75 (NTR) receptors, which belong to the death receptor family (2). Although NGF has been classically described as favoring neuron survival and differentiation, nerve growth factor can promote apoptosis in cells that contain p75 (NTR) and lack TrkA. NGF can induce neuron death in a variety of neurodegenerative conditions, including Alzheimer disease (3). Besides its neurotrophic actions, NGF has an effect on non-neuronal cells and may help mediate inflammation, angiogenesis, and stimulate breast cancer cell growth (4-6). NGF signaling is looking increasingly promising as potential drug targets for diseases.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200

Target (Information from UniProt)
Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
Involvement in Disease: Neuropathy, hereditary sensory and autonomic, 5: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.
Sequence Similarities: Belongs to the NGF-beta family.
Cellular Location: Secreted.

Images
Western Blot - Anti-NGF Antibody from ABclonal (A0258) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using NGF antibody.

Product Code - A0258
Size Price Quantity
50µl £148
100µl £243
200µl £372

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