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Anti-CASP10 Antibody

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ABclonal
A0216
Overview
Name: Anti-CASP10 Antibody
Description: Rabbit polyclonal antibody to CASP10.
Applications: WB, IHC, IF
Dilutions: WB 1:500 - 1:2000, IF 1:50 - 1:200
Reactivity: Human
Immunogen: Recombinant protein of human CASP10
Protein Length: 521(522)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.
Tissue Specificity: Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
Involvement in Disease: Autoimmune lymphoproliferative syndrome 2A: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.

Familial non-Hodgkin lymphoma: Cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.

Gastric cancer: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
UniProt: Q92851
Gene ID: 843
Synonyms: ALPS2 Antibody
Apoptotic protease Mch-4 Antibody
Apoptotic protease Mch4 Antibody
CARS cyclophilin Antibody
CARS Cyp Antibody
CARS-cyclophilin Antibody
CARS-Cyp Antibody
CASP 10 Antibody
CASP-10 Antibody
Caspase 10 Antibody
Caspase 10 apoptosis related cysteine peptidase Antibody
Caspase-10 Antibody
Caspase-10 subunit p12 Antibody
CASPA_HUMAN Antibody
Clk associating RS cyclophilin Antibody
Clk-associating RS-cyclophilin Antibody
Cyclophilin G Antibody
CyclophilinG Antibody
CYP Antibody
FADD like ICE2 Antibody
Fas associated death domain protein Antibody
FAS-associated death domain protein interleukin-1B-converting enzyme 2 Antibody
FLICE 2 Antibody
FLICE2 Antibody
ICE like apoptotic protease 4 Antibody
ICE-like apoptotic protease 4 Antibody
Interleukin 1B converting enzyme 2 Antibody
MCH 4 Antibody
MGC133241 Antibody
Peptidyl prolyl cis trans isomerase G Antibody
Peptidyl prolyl isomerase G Antibody
Peptidyl-prolyl cis-trans isomerase G Antibody
Peptidyl-prolyl isomerase G Antibody
Peptidylprolyl isomerase G Antibody
Peptidylprolyl isomerase G (cyclophilin G) Antibody
PPIase G Antibody
PPIG Antibody
PPIG_HUMAN Antibody
pro Caspase 10 Antibody
Rotamase G Antibody
RotamaseG Antibody
SCAF10 Antibody
SR cyclophilin Antibody
SR cyp Antibody
SR related CTD associated factor 10 Antibody
SR-cyclophilin Antibody
SR-cyp Antibody
SRcyp Antibody

Images
Western Blot - Anti-CASP10 Antibody from ABclonal (A0216) - Antibody Supply Service
Western blot analysis of extracts of Jurkat and NIH3T3 cells, using CASP10 antibody.
Immunofluorescence - Anti-CASP10 Antibody from ABclonal (A0216) - Antibody Supply Service
Immunofluorescence analysis of U20S cell using CASP10 antibody. Blue: DAPI for nuclear staining.

Product Code - A0216
Size Price Quantity
50µl £148
100µl £243
200µl £372

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