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Anti-CDK5R1 Antibody

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ABclonal
A0197
Overview
Name: Anti-CDK5R1 Antibody
Description: Rabbit polyclonal antibody to CDK5R1.
Applications: WB, IHC
Dilutions: WB 1:200 - 1:500, IHC 1:50 - 1:100
Reactivity: Human
Immunogen: A synthetic peptide of human CDK5R1
Protein Length: 307
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
Tissue Specificity: Brain and neuron specific.
Sequence Similarities: Belongs to the cyclin-dependent kinase 5 activator family.
Post-Translational Modification: The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo (By similarity).
Cellular Location: Cell membrane.

In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
UniProt: Q15078
Gene ID: 8851
Synonyms: CD5R1_HUMAN Antibody
CDK5 activator 1 Antibody
CDK5P35 Antibody
CDK5R Antibody
Cyclin dependent kinase 5 regulatory subunit 1 Antibody
Cyclin-dependent kinase 5 activator 1 Antibody
Cyclin-dependent kinase 5 regulatory subunit 1 Antibody
NCK 5A Antibody
Neuronal CDK5 activator Antibody
p23 Antibody
p25 Antibody
p35 Antibody
Regulatory partner for CDK5 kinase Antibody
Tau protein kinase II 23 kDa subunit Antibody
TPKII regulatory subunit Antibody

Images
Western Blot - Anti-CDK5R1 Antibody from ABclonal (A0197) - Antibody Supply Service
Western blot analysis of A2058 cell lysate using CDK5R1 antibody.

Product Code - A0197
Size Price Quantity
100µl £243
200µl £372

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