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Anti-DNMT3A Antibody

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ABclonal
A0193
Overview
Name: Anti-DNMT3A Antibody
Description: Rabbit polyclonal antibody to DNMT3A.
Applications: WB, IHC
Dilutions: WB 1:200 - 1:500
Reactivity: Human
Immunogen: Recombinant protein of human DNMT3A
Protein Length: 912
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Tissue Specificity: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
Involvement in Disease: Tatton-Brown-Rahman syndrome: An overgrowth syndrome characterized by a distinctive facial appearance, tall stature and intellectual disability. Facial gestalt is characterized by a round face, heavy horizontal eyebrows and narrow palpebral fissures. Less common features include atrial septal defects, seizures, umbilical hernia, and scoliosis.
Sequence Similarities: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Post-Translational Modification: Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription.
Cellular Location: Nucleus. Cytoplasm.

Accumulates in the major satellite repeats at pericentric heterochromatin.
UniProt: Q9Y6K1
Gene ID: 1788
Synonyms: DNA (cytosine 5) methyltransferase 3 alpha Antibody
DNA (cytosine 5) methyltransferase 3A Antibody
DNA (cytosine-5)-methyltransferase 3A Antibody
DNA cytosine methyltransferase 3A2 Antibody
DNA methyltransferase 3 alpha Antibody
DNA methyltransferase 3a Antibody
DNA methyltransferase HsaIIIA Antibody
DNA MTase HsaIIIA Antibody
DNM3A_HUMAN Antibody
DNMT Antibody
DNMT 3a Antibody
Dnmt3a (phospho S390 + S393) Antibody
DNMT3A2 Antibody
M.HsaIIIA Antibody
MCMT Antibody
OTTHUMP00000201149 Antibody
TBRS Antibody

Product Code - A0193
Size Price Quantity
100µl £243
200µl £372

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