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Anti-DcR2 Antibody

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Description: Rabbit polyclonal antibody to DcR2.
Category: Primary Antibodies
Applications: WB, FC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q9UBN6
Gene ID: 8793
Immunogen: A synthetic peptide of human TNFRSF10D
Protein Length: 386
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4
Purification: Affinity purification
Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, FC 1:20 - 1:50

Target (Information from UniProt)
Function: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
Tissue Specificity: Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
Cellular Location: Membrane.

Western Blot - Anti-DcR2 Antibody from ABclonal (A0184) - Antibody Supply Service
Western blot analysis of extracts of A549 cell line, using TNFRSF10D antibody.

Product Code - A0184
Size Price Quantity
100µl £243
200µl £372

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