|Description:||Rabbit polyclonal antibody to TRADD.|
|Applications:||WB, IHC, IF, FC|
|Dilutions:||WB 1:500 - 1:1000, IHC 1:50 - 1:100, IF 1:20 - 1:50, FC 1:20 - 1:50|
|Immunogen:||A synthetic peptide of human TRADD|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at 4℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.|
|Tissue Specificity:||Found in all examined tissues.|
|Cellular Location:||Nucleus. Cytoplasm. Cytoplasm > Cytoskeleton.
Shuttles between the cytoplasm and the nucleus.
TNFR1 associated DEATH domain protein Antibody
TNFR1-associated DEATH domain protein Antibody
TNFRSF1A associated via death domain Antibody
TNFRSF1A-associated via death domain Antibody
Tumor necrosis factor receptor type 1 associated DEATH domain protein Antibody
Tumor necrosis factor receptor type 1-associated DEATH domain protein Antibody
Western blot analysis of extracts of HeLa cells, using TRADD antibody.