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Anti-Hexokinase II Antibody

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ABclonal
A0165
Details
Description: Rabbit polyclonal antibody to Hexokinase II.
Category: Primary Antibodies
Applications: WB, IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P52789
Gene ID: 3099
Immunogen: A synthetic peptide of human HK2
Protein Length: 917
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: Hexokinase II; HK2; DKFZp686M1669; HKII; HXK2
Purification: Affinity purification
Background: Hexokinase catalyzes the conversion of glucose to glucose-6-phosphate, the first step in glycolysis. Four distinct mammalian hexokinase isoforms, designated as hexokinase I, II, III and IV (glucokinase), have been identified. Hexokinases I, II and III are associated with the outer mitochondrial membrane and are critical for maintaining an elevated rate of aerobic glycolysis in cancer cells (Warburg Effect) (1) in order to compensate for the increased energy demands associated with rapid cell growth and proliferation (2,3).
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:100

Target (Information from UniProt)
Tissue Specificity: Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.
Sequence Similarities: Belongs to the hexokinase family.
Cellular Location: Mitochondrion outer membrane.

Its hydrophobic N-terminal sequence may be involved in membrane binding.

Images
Western Blot - Anti-Hexokinase II Antibody from ABclonal (A0165) - Antibody Supply Service
Western blot analysis of extracts of HeLa cells, using HK2 antibody.

Product Code - A0165
Size Price Quantity
100µl £243
200µl £372

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